Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production
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Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production
Isoprenoids are natural products that are all derived from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). These precursors are synthesized either by the mevalonate (MVA) pathway or the 1-Deoxy-D-Xylulose 5-Phosphate (DXP) pathway. Metabolic engineering of microbes has enabled overproduction of various isoprenoid products from the DXP pathway including lycopene, artemisinic...
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1 CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Portugal; 7 [email protected] 8 2 Institute of Microbiology, Faculty of Medicine, University of Coimbra, Portugal 9 3 CEDOC, NOVA Medical School, Universidade NOVA de Lisboa, Rua Camara Pestana, no6, 6A, edifício II, 10 piso 3, 1150-082 Lisbon, Portugal 11 4 CICECO-Department of Chemistry, University of Aveiro,...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0047513